Lung cancer is the most common cause of cancer death worldwide and in the United States (1). Estimates are that approximately 160,000 Americans will die of lung cancer in 2012.
While genetic susceptibility plays a role in lung cancer risk, cigarette smoking is by far the most important risk factor. Smokers are as much as 23 times more likely to develop lung cancer than non-smokers. Cigar and pipe smoking also increase risk. Other risks include exposure to radon gas released from soil and building materials, and occupational or environmental exposure to secondhand smoke, asbestos (particularly among smokers), certain metals (chromium, cadmium, arsenic), some organic chemicals, radiation, air pollution, and paint (occupational)….